I have about 1100 miles on my flhxse2. My rear shocks are adjusted to my weight for solo which is under 200 lbs. On a smooth hwy the ride is fine. A few pebbles on the road, or bumpy road, and after some miles, I really feel the fatigue. On my SEUC4 I have Traxxion Dynamics front forks and Bitubo rear shocks. On my SEUC5 I have Traxxion on the front and Ohlins on the rear. The Bitubos and Ohlins are comparable but I'd definitely give the edge to Ohlins.
After not riding my Ultras since I bought the SESG, I took a ride today on my SEUC5. Man, did I realize how much of a difference my suspension made on the comfort of a ride. I'll be adding suspension mods to the SG soon.